The PSL 2021 new schedule had to be brought into force after scrapping the old schedule when the tournament got suspended in the month of March. As per the old schedule, Karachi Kings, Peshawar Zalmi, Multan Sultans, and Quetta Gladiators had played 5 games each while Islamabad United and Lahore Qalandars had played 4 games each.
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PSL 2021 New Schedule
| Date | Match | Venue | Time |
| 01 June 2021 | Lahore Qalandars vs Islamabad United | Sheikh Zayed Cricket Stadium, Abu Dhabi | 08:30 PM IST |
| 02 June 2021 | Multan Sultans vs Karachi Kings | Sheikh Zayed Cricket Stadium, Abu Dhabi | 08:30 PM IST |
| 03 June 2021 | Islamabad United vs Quetta Gladiators | Sheikh Zayed Cricket Stadium, Abu Dhabi | 08:30 PM IST |
| 04 June 2021 | Peshawar Zalmi vs Lahore Qalandars | Sheikh Zayed Cricket Stadium, Abu Dhabi | 08:30 PM IST |
| 05 June 2021 | Islamabad United vs Karachi Kings | Sheikh Zayed Cricket Stadium, Abu Dhabi | 05:30 PM IST |
| 05 June 2021 | Multan Sultans vs Quetta Gladiators | Sheikh Zayed Cricket Stadium, Abu Dhabi | 10:30 PM IST |
| 06 June 2021 | Peshawar Zalmi vs Karachi Kings | Sheikh Zayed Cricket Stadium, Abu Dhabi | 11:30 PM IST |
| 07 June 2021 | Quetta Gladiators vs Lahore Qalandars | Sheikh Zayed Cricket Stadium, Abu Dhabi | 08:30 PM IST |
| 08 June 2021 | Multan Sultans vs Peshawar Zalmi | Sheikh Zayed Cricket Stadium, Abu Dhabi | 08:30 PM IST |
| 09 June 2021 | Islamabad United vs Lahore Qalandars | Sheikh Zayed Cricket Stadium, Abu Dhabi | 08:30 PM IST |
| 10 June 2021 | Quetta Gladiators vs Karachi Kings | Sheikh Zayed Cricket Stadium, Abu Dhabi | 08:30 PM IST |
| 11 June 2021 | Multan Sultans vs Islamabad United | Sheikh Zayed Cricket Stadium, Abu Dhabi | 08:30 PM IST |
| 12 June 2021 | Quetta Gladiators vs Peshawar Zalmi | Sheikh Zayed Cricket Stadium, Abu Dhabi | 05:30 PM IST |
| 13 June 2021 | Karachi Kings vs Lahore Qalandars | Sheikh Zayed Cricket Stadium, Abu Dhabi | 01:30 AM IST |
| 13 June 2021 | Islamabad United vs Peshawar Zalmi | Sheikh Zayed Cricket Stadium, Abu Dhabi | 08:30 PM IST |
| 14 June 2021 | Multan Sultans vs Lahore Qalandars | Sheikh Zayed Cricket Stadium, Abu Dhabi | 08:30 PM IST |
| 16 June 2021 | Qualifier (Team 1 vs Team 2) | Sheikh Zayed Cricket Stadium, Abu Dhabi | 08:30 PM IST |
| 17 June 2021 | Eliminator 1 (Team 3 vs Team 4) | Sheikh Zayed Cricket Stadium, Abu Dhabi | 08:30 PM IST |
| 18 June 2021 | Eliminator 2 (Loser Qualifier vs Winner Eliminator 1) | Sheikh Zayed Cricket Stadium, Abu Dhabi | 08:30 PM IST |
| 20 June 2021 | Final | Sheikh Zayed Cricket Stadium, Abu Dhabi | 08:30 PM IST |
